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Sleep research
ISRIB
30mL, 20mg/mL
Dual orexin receptor antagonist for sleep research.
Overview
ISRIB (Integrated Stress Response Inhibitor) is a small molecule that reverses the effects of eIF2α phosphorylation. It is studied extensively in cognitive and memory research to understand its impact on cellular stress responses.
Mechanism of action
It promotes protein synthesis by preventing the inhibition caused by phosphorylated eIF2α.
Dosage & concentration
20 mg/mL concentration. 30 mL bottle contains 600 mg total.
Storage & handling
Store at -20°C for long-term stability.
Research & studies
- The integrated stress response: From mechanism to disease.Science · 2020
- ALSUntangled #80: ISRIB (Integrated stress response InhiBitor).Amyotroph Lateral Scler Frontotemporal Degener · 2025
- ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.Mol Cell · 2021